A healthier you, made simple and affordable.
A healthier you, made simple and affordable.
A healthier you, made simple and affordable.
Our Mochi doctors prescribe the most effective and appropriate medication for our patients. We provide all options from GLP-1's to generic medication. Read over what medications we prescribe below!
Our Mochi doctors prescribe the most effective and appropriate medication for our patients. We provide all options from GLP-1's to generic medication. Read over what medications we prescribe below!
Our Mochi doctors prescribe the most effective and appropriate medication for our patients. We provide all options from GLP-1's to generic medication. Read over what medications we prescribe below!
Medications
Weight Loss
Anti-aging & Wellness
Skincare & Hair loss
Hormones
Mental Health
Reflux & Nausea
Compounded Medication
A Mochi provider may prescribe a compounded medication if they determine that such medication is an appropriate part of your course of treatment. Find out if you’re eligible below.
How it works
Compounded medications are custom-prepared to meet an individual patient's specific needs. For example, they may include a specific dosage strength not available commercially or additional active ingredients clinically indicated for the patient. These medications are created by licensed pharmacies, based on a valid prescription from a licensed provider. While they are not FDA-approved (meaning they haven’t gone through the FDA drug approval process), they are still regulated at the state and/or federal level, and must meet important safety and quality standards.
Expected results
Results may vary depending on individual goals and health status. Talk with your Mochi provider to understand what to expect when taking compounded medication. They'll work with you to determine the most effective treatment plan for your needs.
Side effects
Side effects depend on the medication prescribed and individual tolerance. Common side effects of compounded GLP-1 medication include nausea, vomiting, and diarrhea, and they typically subside within a few weeks of initiation or dose increase. Your provider will help you monitor and manage side effects.
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia. Other contraindications may be present – providers will review health history to determine whether a prescription is appropriate.
Wegovy® / Ozempic®
Active ingredient: Semaglutide
Semaglutide is a GLP-1 agonist created for Type 2 Diabetes and FDA-approved in 2019. It was approved for the indication of weight loss as Wegovy® in June 2021.
How it works
GLP-1 works to increase insulin levels by activating cells in the pancreas. It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea.
Expected results
When used alongside robust lifestyle management (200 min exercise/week, nutri-system diet, bimonthly nutritionist visits) patients observed 10-14% weight loss, maintained over 2 years (STEP3 Trial, Novo Nordisk). (Wilding et al., 2021)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Mounjaro® / Zepbound®
Active ingredient: Tirzepatide
Tirzepatide is the newest form of weight loss medication. It was recently approved for Type 2 diabetes, and works through both the GLP-1 receptor and GIP receptors.
How it works
Both GLP-1 and GIP receptors work to decrease the rate your stomach empties-keeping you full for longer! They also work to decrease your appetite and cravings.
Expected results
The SURMOUNT-1 trial showed expected weight loss of 22.5%. Additional trials have shown this medication is twice as effective as Semaglutide 1.0mg. (Aronne et al., 2024)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
Chronic malabsorption; pregnancy; cholestasis/history of gallbladder disease; pancreatitis; family history of thyroid cancer; thyroid disorders
Saxenda® / Victoza®
Active ingredient: Liraglutide
Liraglutide is a GLP-1 agonist medication, very similar to Semaglutide. It was initially developed as a medication for Type 2 Diabetes, but found to also help patients with weight loss.
How it works
By activating GLP-1 receptors, this medication works to slow the rate at which your stomach empties, and to send signals to your brain to decrease appetite.
Expected results
The SCALE Trial showed patients can lose 6.2% over 52 weeks (CI 7.5 to 4.6%). (Rubino et al., 2022)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
Pancreatitis gallstones; family history of thyroid cancer; thyroid disorders
Rybelsus®
Active ingredient: Semaglutide
Semaglutide is a GLP-1 agonist created for Type 2 Diabetes and FDA-approved in 2019. It was approved for the indication of weight loss as Wegovy® in June 2021.
How it works
GLP-1 works to increase insulin levels by activating cells in the pancreas. It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea.
Expected results
When used alongside robust lifestyle management (200 min exercise/week, nutri-system diet, bimonthly nutritionist visits) patients observed 10-14% weight loss, maintained over 2 years (STEP3 Trial, Novo Nordisk). (Wilding et al., 2021)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Topamax® / Qudexy® / Trokendi XR®
Active ingredient: Topiramate
Topiramate, a medication originally created to treat epilepsy, was approved by the FDA in 1998. It is used off-label for weight loss, often in conjunction with Phentermine. It can be used short- or long-term for weight loss safely.
How it works
Topiramate alters a variety of GABA and Glutamate channels in the brain to suppress cravings and appetite.
Expected results
Topiramate has independently shown results in meta-analysis of 5.34kg weight loss (95% CI 4.56my-10 lg:-6.12kg). In conjunction with Phentermine, the CONQUER and SEQUEL Trials Showed as high as 10.7% weight loss in low-dose and 14% in high-dose groups maintained over 2 years. (Wilding et al., 2004)
Side effects
Dizziness (<1%); paresthesias (5%); anxiety (1.1%); headache (1.7%)
Avoid when
History of kidney stones; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Zyban® / Contrave® / Aplenzin XR®
Active ingredient: Bupropion
Bupropion was initially approved as a medication for anxiety and depression. It is also used as a smoking cessation aid, as it reduces cravings and alters mood. It is prescribed off-label either alone or with naltrexone for weight loss, and also as a combo pill (Contrave®).
How it works
Bupropion works by inhibiting neurotransmitter reuptake of norepinephrine and dopamine. By holding higher concentrations of these in the brain, neurons increase signaling and alter hunger and mood.
Expected results
Bupropion has been studied extensively, both independently and in conjunction with naltrexone (Contrave®). The COR-I, COR-II, COR-BMOD, and COR-Diabetes trials demonstrated 8.1-11.5% weight loss over 2 years. (Greenway et al., 2010)
Side effects
Activation of mania in bipolar patients (<1%); insomnia (11-40%)
Avoid when
History of bipolar disorder; schizophrenia; hypertension; concurrent substance use disorder
Apo-Naltrexone® / ReVia®
Active ingredient: Naltrexone
Naltrexone was developed as a medication for alcohol and substance use disorder. However, as its mechanism is to stop cravings, it has long been prescribed for weight loss. It is a component in the combination pill, Contrave®.
How it works
Naltrexone is a mu-receptor antagonist. This inhibits the effects on the hypothalamic-pituitary-adrenal axis from this receptor, and thus suppresses appetite and cravings.
Expected results
Naltrexone has been studied both independently and as a component in Contrave® (8.1-11.5% weight loss when used with bupropion). (Apovian et al., 2013)
Side effects
Abdominal pain (11%); anxiety-10 lg:y (12%); headache (25%)
Avoid when
History of anorexia/bulimia; concurrent substance use disorder; use of opiates; pregnant; breastfeeding; trying to conceive
Xenical® / Alli®
Active ingredient: Orlistat
Orlistat is a pancreatic lipase inhibitor that was created to block intestinal absorption of fat. It was created for the indication of weight loss, and FDA approved in 1999.
How it works
Orlistat works directly as a lipase inhibitor. By blocking the breakdown of fats in the intestines, fats cannot be absorbed and are excreted in stool.
Expected results
Orlistat is associated with a modest reduction in weight: meta-analysis including 11 randomized control trials using 120mg of orlistat 3 times per day showed 2.9% greater weight loss than placebo. (Khera et al., 2016)
Side effects
Oily spotting (26%); flatus with discharge (23.9%); fecal urgency (22.1%); fatty/oily stool (20.0%); oily evacuation (11.9%); increased risk of vitamin D, E, A, K deficiency
Avoid when
Chronic malabsorption; pregnancy; cholestasis/history of gallbladder disease
All Treatments
Bupropion SR
Bupriopion XL
Contrave
Low Dose Naltrexone
Metformin
Metformin ER
Mounjaro® (Tirzepatide)
Ondansetron (generic for Zofran®)
Ozempic® (Semaglutide)
Rybelsus® (Semaglutide)
Saxenda® (Liraglutide)
Topiramate
Trulicity® (Dulaglutide)
Victoza® (Liraglutide)
Wegovy® (Semaglutide)
Zepbound® (Tirzepatide)
Zofran® (Ondansetron)
Medications
Weight Loss
Anti-aging & Wellness
Skincare & Hair loss
Hormones
Mental Health
Reflux & Nausea
Compounded Medication
A Mochi provider may prescribe a compounded medication if they determine that such medication is an appropriate part of your course of treatment. Find out if you’re eligible below.
How it works
Compounded medications are custom-prepared to meet an individual patient's specific needs. For example, they may include a specific dosage strength not available commercially or additional active ingredients clinically indicated for the patient. These medications are created by licensed pharmacies, based on a valid prescription from a licensed provider. While they are not FDA-approved (meaning they haven’t gone through the FDA drug approval process), they are still regulated at the state and/or federal level, and must meet important safety and quality standards.
Expected results
Results may vary depending on individual goals and health status. Talk with your Mochi provider to understand what to expect when taking compounded medication. They'll work with you to determine the most effective treatment plan for your needs.
Side effects
Side effects depend on the medication prescribed and individual tolerance. Common side effects of compounded GLP-1 medication include nausea, vomiting, and diarrhea, and they typically subside within a few weeks of initiation or dose increase. Your provider will help you monitor and manage side effects.
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia. Other contraindications may be present – providers will review health history to determine whether a prescription is appropriate.
Wegovy® / Ozempic®
Active ingredient: Semaglutide
Semaglutide is a GLP-1 agonist created for Type 2 Diabetes and FDA-approved in 2019. It was approved for the indication of weight loss as Wegovy® in June 2021.
How it works
GLP-1 works to increase insulin levels by activating cells in the pancreas. It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea.
Expected results
When used alongside robust lifestyle management (200 min exercise/week, nutri-system diet, bimonthly nutritionist visits) patients observed 10-14% weight loss, maintained over 2 years (STEP3 Trial, Novo Nordisk). (Wilding et al., 2021)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Mounjaro® / Zepbound®
Active ingredient: Tirzepatide
Tirzepatide is the newest form of weight loss medication. It was recently approved for Type 2 diabetes, and works through both the GLP-1 receptor and GIP receptors.
How it works
Both GLP-1 and GIP receptors work to decrease the rate your stomach empties-keeping you full for longer! They also work to decrease your appetite and cravings.
Expected results
The SURMOUNT-1 trial showed expected weight loss of 22.5%. Additional trials have shown this medication is twice as effective as Semaglutide 1.0mg. (Aronne et al., 2024)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
Chronic malabsorption; pregnancy; cholestasis/history of gallbladder disease; pancreatitis; family history of thyroid cancer; thyroid disorders
Saxenda® / Victoza®
Active ingredient: Liraglutide
Liraglutide is a GLP-1 agonist medication, very similar to Semaglutide. It was initially developed as a medication for Type 2 Diabetes, but found to also help patients with weight loss.
How it works
By activating GLP-1 receptors, this medication works to slow the rate at which your stomach empties, and to send signals to your brain to decrease appetite.
Expected results
The SCALE Trial showed patients can lose 6.2% over 52 weeks (CI 7.5 to 4.6%). (Rubino et al., 2022)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
Pancreatitis gallstones; family history of thyroid cancer; thyroid disorders
Rybelsus®
Active ingredient: Semaglutide
Semaglutide is a GLP-1 agonist created for Type 2 Diabetes and FDA-approved in 2019. It was approved for the indication of weight loss as Wegovy® in June 2021.
How it works
GLP-1 works to increase insulin levels by activating cells in the pancreas. It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea.
Expected results
When used alongside robust lifestyle management (200 min exercise/week, nutri-system diet, bimonthly nutritionist visits) patients observed 10-14% weight loss, maintained over 2 years (STEP3 Trial, Novo Nordisk). (Wilding et al., 2021)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Topamax® / Qudexy® / Trokendi XR®
Active ingredient: Topiramate
Topiramate, a medication originally created to treat epilepsy, was approved by the FDA in 1998. It is used off-label for weight loss, often in conjunction with Phentermine. It can be used short- or long-term for weight loss safely.
How it works
Topiramate alters a variety of GABA and Glutamate channels in the brain to suppress cravings and appetite.
Expected results
Topiramate has independently shown results in meta-analysis of 5.34kg weight loss (95% CI 4.56my-10 lg:-6.12kg). In conjunction with Phentermine, the CONQUER and SEQUEL Trials Showed as high as 10.7% weight loss in low-dose and 14% in high-dose groups maintained over 2 years. (Wilding et al., 2004)
Side effects
Dizziness (<1%); paresthesias (5%); anxiety (1.1%); headache (1.7%)
Avoid when
History of kidney stones; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Zyban® / Contrave® / Aplenzin XR®
Active ingredient: Bupropion
Bupropion was initially approved as a medication for anxiety and depression. It is also used as a smoking cessation aid, as it reduces cravings and alters mood. It is prescribed off-label either alone or with naltrexone for weight loss, and also as a combo pill (Contrave®).
How it works
Bupropion works by inhibiting neurotransmitter reuptake of norepinephrine and dopamine. By holding higher concentrations of these in the brain, neurons increase signaling and alter hunger and mood.
Expected results
Bupropion has been studied extensively, both independently and in conjunction with naltrexone (Contrave®). The COR-I, COR-II, COR-BMOD, and COR-Diabetes trials demonstrated 8.1-11.5% weight loss over 2 years. (Greenway et al., 2010)
Side effects
Activation of mania in bipolar patients (<1%); insomnia (11-40%)
Avoid when
History of bipolar disorder; schizophrenia; hypertension; concurrent substance use disorder
Apo-Naltrexone® / ReVia®
Active ingredient: Naltrexone
Naltrexone was developed as a medication for alcohol and substance use disorder. However, as its mechanism is to stop cravings, it has long been prescribed for weight loss. It is a component in the combination pill, Contrave®.
How it works
Naltrexone is a mu-receptor antagonist. This inhibits the effects on the hypothalamic-pituitary-adrenal axis from this receptor, and thus suppresses appetite and cravings.
Expected results
Naltrexone has been studied both independently and as a component in Contrave® (8.1-11.5% weight loss when used with bupropion). (Apovian et al., 2013)
Side effects
Abdominal pain (11%); anxiety-10 lg:y (12%); headache (25%)
Avoid when
History of anorexia/bulimia; concurrent substance use disorder; use of opiates; pregnant; breastfeeding; trying to conceive
Xenical® / Alli®
Active ingredient: Orlistat
Orlistat is a pancreatic lipase inhibitor that was created to block intestinal absorption of fat. It was created for the indication of weight loss, and FDA approved in 1999.
How it works
Orlistat works directly as a lipase inhibitor. By blocking the breakdown of fats in the intestines, fats cannot be absorbed and are excreted in stool.
Expected results
Orlistat is associated with a modest reduction in weight: meta-analysis including 11 randomized control trials using 120mg of orlistat 3 times per day showed 2.9% greater weight loss than placebo. (Khera et al., 2016)
Side effects
Oily spotting (26%); flatus with discharge (23.9%); fecal urgency (22.1%); fatty/oily stool (20.0%); oily evacuation (11.9%); increased risk of vitamin D, E, A, K deficiency
Avoid when
Chronic malabsorption; pregnancy; cholestasis/history of gallbladder disease
All Treatments
Bupropion SR
Bupriopion XL
Contrave
Low Dose Naltrexone
Metformin
Metformin ER
Mounjaro® (Tirzepatide)
Ondansetron (generic for Zofran®)
Ozempic® (Semaglutide)
Rybelsus® (Semaglutide)
Saxenda® (Liraglutide)
Topiramate
Trulicity® (Dulaglutide)
Victoza® (Liraglutide)
Wegovy® (Semaglutide)
Zepbound® (Tirzepatide)
Zofran® (Ondansetron)
Medications
Weight Loss
Anti-aging & Wellness
Skincare & Hair loss
Hormones
Mental Health
Reflux & Nausea
Compounded Medication
A Mochi provider may prescribe a compounded medication if they determine that such medication is an appropriate part of your course of treatment. Find out if you’re eligible below.
How it works
Compounded medications are custom-prepared to meet an individual patient's specific needs. For example, they may include a specific dosage strength not available commercially or additional active ingredients clinically indicated for the patient. These medications are created by licensed pharmacies, based on a valid prescription from a licensed provider. While they are not FDA-approved (meaning they haven’t gone through the FDA drug approval process), they are still regulated at the state and/or federal level, and must meet important safety and quality standards.
Expected results
Results may vary depending on individual goals and health status. Talk with your Mochi provider to understand what to expect when taking compounded medication. They'll work with you to determine the most effective treatment plan for your needs.
Side effects
Side effects depend on the medication prescribed and individual tolerance. Common side effects of compounded GLP-1 medication include nausea, vomiting, and diarrhea, and they typically subside within a few weeks of initiation or dose increase. Your provider will help you monitor and manage side effects.
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia. Other contraindications may be present – providers will review health history to determine whether a prescription is appropriate.
Wegovy® / Ozempic®
Active ingredient: Semaglutide
Semaglutide is a GLP-1 agonist created for Type 2 Diabetes and FDA-approved in 2019. It was approved for the indication of weight loss as Wegovy® in June 2021.
How it works
GLP-1 works to increase insulin levels by activating cells in the pancreas. It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea.
Expected results
When used alongside robust lifestyle management (200 min exercise/week, nutri-system diet, bimonthly nutritionist visits) patients observed 10-14% weight loss, maintained over 2 years (STEP3 Trial, Novo Nordisk). (Wilding et al., 2021)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Mounjaro® / Zepbound®
Active ingredient: Tirzepatide
Tirzepatide is the newest form of weight loss medication. It was recently approved for Type 2 diabetes, and works through both the GLP-1 receptor and GIP receptors.
How it works
Both GLP-1 and GIP receptors work to decrease the rate your stomach empties-keeping you full for longer! They also work to decrease your appetite and cravings.
Expected results
The SURMOUNT-1 trial showed expected weight loss of 22.5%. Additional trials have shown this medication is twice as effective as Semaglutide 1.0mg. (Aronne et al., 2024)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
Chronic malabsorption; pregnancy; cholestasis/history of gallbladder disease; pancreatitis; family history of thyroid cancer; thyroid disorders
Saxenda® / Victoza®
Active ingredient: Liraglutide
Liraglutide is a GLP-1 agonist medication, very similar to Semaglutide. It was initially developed as a medication for Type 2 Diabetes, but found to also help patients with weight loss.
How it works
By activating GLP-1 receptors, this medication works to slow the rate at which your stomach empties, and to send signals to your brain to decrease appetite.
Expected results
The SCALE Trial showed patients can lose 6.2% over 52 weeks (CI 7.5 to 4.6%). (Rubino et al., 2022)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
Pancreatitis gallstones; family history of thyroid cancer; thyroid disorders
Rybelsus®
Active ingredient: Semaglutide
Semaglutide is a GLP-1 agonist created for Type 2 Diabetes and FDA-approved in 2019. It was approved for the indication of weight loss as Wegovy® in June 2021.
How it works
GLP-1 works to increase insulin levels by activating cells in the pancreas. It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea.
Expected results
When used alongside robust lifestyle management (200 min exercise/week, nutri-system diet, bimonthly nutritionist visits) patients observed 10-14% weight loss, maintained over 2 years (STEP3 Trial, Novo Nordisk). (Wilding et al., 2021)
Side effects
Nausea (44%); vomiting (25%); diarrhea/GI distress (30%)
Avoid when
History of thyroid C-cell tumors; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Topamax® / Qudexy® / Trokendi XR®
Active ingredient: Topiramate
Topiramate, a medication originally created to treat epilepsy, was approved by the FDA in 1998. It is used off-label for weight loss, often in conjunction with Phentermine. It can be used short- or long-term for weight loss safely.
How it works
Topiramate alters a variety of GABA and Glutamate channels in the brain to suppress cravings and appetite.
Expected results
Topiramate has independently shown results in meta-analysis of 5.34kg weight loss (95% CI 4.56my-10 lg:-6.12kg). In conjunction with Phentermine, the CONQUER and SEQUEL Trials Showed as high as 10.7% weight loss in low-dose and 14% in high-dose groups maintained over 2 years. (Wilding et al., 2004)
Side effects
Dizziness (<1%); paresthesias (5%); anxiety (1.1%); headache (1.7%)
Avoid when
History of kidney stones; pregnant; breastfeeding; trying to conceive; history of anorexia/bulimia
Zyban® / Contrave® / Aplenzin XR®
Active ingredient: Bupropion
Bupropion was initially approved as a medication for anxiety and depression. It is also used as a smoking cessation aid, as it reduces cravings and alters mood. It is prescribed off-label either alone or with naltrexone for weight loss, and also as a combo pill (Contrave®).
How it works
Bupropion works by inhibiting neurotransmitter reuptake of norepinephrine and dopamine. By holding higher concentrations of these in the brain, neurons increase signaling and alter hunger and mood.
Expected results
Bupropion has been studied extensively, both independently and in conjunction with naltrexone (Contrave®). The COR-I, COR-II, COR-BMOD, and COR-Diabetes trials demonstrated 8.1-11.5% weight loss over 2 years. (Greenway et al., 2010)
Side effects
Activation of mania in bipolar patients (<1%); insomnia (11-40%)
Avoid when
History of bipolar disorder; schizophrenia; hypertension; concurrent substance use disorder
Apo-Naltrexone® / ReVia®
Active ingredient: Naltrexone
Naltrexone was developed as a medication for alcohol and substance use disorder. However, as its mechanism is to stop cravings, it has long been prescribed for weight loss. It is a component in the combination pill, Contrave®.
How it works
Naltrexone is a mu-receptor antagonist. This inhibits the effects on the hypothalamic-pituitary-adrenal axis from this receptor, and thus suppresses appetite and cravings.
Expected results
Naltrexone has been studied both independently and as a component in Contrave® (8.1-11.5% weight loss when used with bupropion). (Apovian et al., 2013)
Side effects
Abdominal pain (11%); anxiety-10 lg:y (12%); headache (25%)
Avoid when
History of anorexia/bulimia; concurrent substance use disorder; use of opiates; pregnant; breastfeeding; trying to conceive
Xenical® / Alli®
Active ingredient: Orlistat
Orlistat is a pancreatic lipase inhibitor that was created to block intestinal absorption of fat. It was created for the indication of weight loss, and FDA approved in 1999.
How it works
Orlistat works directly as a lipase inhibitor. By blocking the breakdown of fats in the intestines, fats cannot be absorbed and are excreted in stool.
Expected results
Orlistat is associated with a modest reduction in weight: meta-analysis including 11 randomized control trials using 120mg of orlistat 3 times per day showed 2.9% greater weight loss than placebo. (Khera et al., 2016)
Side effects
Oily spotting (26%); flatus with discharge (23.9%); fecal urgency (22.1%); fatty/oily stool (20.0%); oily evacuation (11.9%); increased risk of vitamin D, E, A, K deficiency
Avoid when
Chronic malabsorption; pregnancy; cholestasis/history of gallbladder disease
All Treatments
Bupropion SR
Bupriopion XL
Contrave
Low Dose Naltrexone
Metformin
Metformin ER
Mounjaro® (Tirzepatide)
Ondansetron (generic for Zofran®)
Ozempic® (Semaglutide)
Rybelsus® (Semaglutide)
Saxenda® (Liraglutide)
Topiramate
Trulicity® (Dulaglutide)
Victoza® (Liraglutide)
Wegovy® (Semaglutide)
Zepbound® (Tirzepatide)
Zofran® (Ondansetron)
© 2025 Mochi Health
All professional medical services are provided by licensed physicians and clinicians affiliated with independently owned and operated professional practices. Mochi Health Corp. provides administrative and technology services to affiliated medical practices it supports, and does not provide any professional medical services itself.
© 2025 Mochi Health
All professional medical services are provided by licensed physicians and clinicians affiliated with independently owned and operated professional practices. Mochi Health Corp. provides administrative and technology services to affiliated medical practices it supports, and does not provide any professional medical services itself.
© 2025 Mochi Health
All professional medical services are provided by licensed physicians and clinicians affiliated with independently owned and operated professional practices. Mochi Health Corp. provides administrative and technology services to affiliated medical practices it supports, and does not provide any professional medical services itself.