Mental Health
Bupropion
An atypical antidepressant FDA-approved for depression, seasonal affective disorder, and smoking cessation.
*Requires a Mochi Health Membership. Cost of medication not included in Mochi Health Membership Fee
Rated 4.5 / 5 based on 16,074 reviews
Results
The goals our members are reaching
Treats Depression
1
FDA-approved for major depressive disorder.
Seasonal Affective Disorder
2
FDA-approved for seasonal affective disorder.
Helps Quit Smoking
3
FDA-approved (as Zyban) for smoking cessation.
Component of Contrave
4
Combined with naltrexone in the FDA-approved Contrave product for chronic weight management.
Different Mechanism
5
Affects norepinephrine and dopamine activity rather than serotonin like SSRIs.
Multiple Formulations
6
Available in immediate-release, sustained-release, and extended-release forms.
The treatment
Understanding the treatment
Active Ingredient:
Bupropion hydrochloride
Bupropion is an atypical antidepressant that increases norepinephrine and dopamine activity in the brain (rather than serotonin like SSRIs). It is FDA-approved for major depressive disorder, seasonal affective disorder, and (as Zyban) smoking cessation. In combination with naltrexone in the FDA-approved product Contrave, bupropion is also approved for chronic weight management. Bupropion is typically taken earlier in the day to minimize the chance of insomnia.
Side effects
Most common: dry mouth, insomnia, headache, nausea, agitation, increased heart rate, sweating, and decreased appetite. Less common but important: increased blood pressure, anxiety or jitteriness, and — rarely — seizures (dose-dependent risk). Also: increased suicidal thoughts in young adults and rare allergic skin reactions.
Avoid When
History of seizure disorder; current or prior eating disorder (anorexia or bulimia); abrupt discontinuation of alcohol, benzodiazepines, or other sedatives; concurrent MAO inhibitors; known hypersensitivity. Use caution with hypertension, bipolar disorder, recent head injury, or kidney/liver disease.
How it works
Getting started should feel simple
From eligibility to ongoing care, Mochi is designed to make each step clear, supportive, and easy to follow.
Personalized care
The medication is
the smaller part
Mochi pairs you with a physician, care team, pharmacist, and personalized plan designed to support your body, progress, and long-term goals over time.
Our expertise
You deserve doctors who listen
Rated 4.5 / 5 based on 16,074 reviews
Testimonials
FAQ
Everything you need to know
Dr. Roberto Valledor
Doctor certified
FAQ
01
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02
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