Can Ozempic® Cause Constipation: Understanding the Side Effects

Final Tips For Managing Ozempic® Side Effects

In conclusion, while Ozempic® and other GLP-1 medications can cause constipation in some individuals, this side effect is often manageable through dietary and lifestyle modifications. If you're experiencing constipation or other side effects while on these medications, it's vital to consult with your healthcare provider for personalized advice and management strategies. Remember, the goal is to manage your diabetes effectively without compromising your overall quality of life.

If you want personalized guidance from an obesity medicine physician, consider joining Mochi Health’s comprehensive weight care program. Find out if you’re eligible today!

References:

1. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989–1002. https://www.nejm.org/doi/10.1056/NEJMoa2032183?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

2. Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2011). Effects of GLP-1 and incretin-based therapies on gastrointestinal motor function. Experimental diabetes research, 2011, 279530. https://onlinelibrary.wiley.com/doi/10.1155/2011/279530

3. Tramonte, S. M., Brand, M. B., Mulrow, C. D., Amato, M. G., O'Keefe, M. E., & Ramirez, G. (1997). The treatment of chronic constipation in adults. A systematic review. Journal of general internal medicine, 12(1), 15–24. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9034942/

4. Attaluri, A., Donahoe, R., Valestin, J., Brown, K., & Rao, S. S. (2011). Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Alimentary pharmacology & therapeutics, 33(7), 822–828. https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04594.x

5. Arnaud M. J. (2003). Mild dehydration: a risk factor of constipation?. European journal of clinical nutrition, 57 Suppl 2, S88–S95. https://doi.org/10.1038/sj.ejcn.1601907

6. Gao, R., Tao, Y., Zhou, C., Li, J., Wang, X., Chen, L., Li, F., & Guo, L. (2019). Exercise therapy in patients with constipation: a systematic review and meta-analysis of randomized controlled trials. Scandinavian journal of gastroenterology, 54(2), 169–177. https://doi.org/10.1080/00365521.2019.1568544

7. Wharton, S., Calanna, S., Davies, M., Dicker, D., Goldman, B., Lingvay, I., Mosenzon, O., Rubino, D. M., Thomsen, M., Wadden, T. A., & Pedersen, S. D. (2022). Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss. Diabetes, obesity & metabolism, 24(1), 94–105. https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14551

8. Smith, L. L., Mosley, J. F., 2nd, Parke, C., Brown, J., Barris, L. S., & Phan, L. D. (2016). Dulaglutide (Trulicity): The Third Once-Weekly GLP-1 Agonist. P & T : a peer-reviewed journal for formulary management, 41(6), 357–360. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27313432/

9. Davies, M. J., Bergenstal, R., Bode, B., Kushner, R. F., Lewin, A., Skjøth, T. V., Andreasen, A. H., Jensen, C. B., DeFronzo, R. A., & NN8022-1922 Study Group (2015). Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial. JAMA, 314(7), 687–699. https://doi.org/10.1001/jama.2015.9676‍

10. Madsbad S. (2016). Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists. Diabetes, obesity & metabolism, 18(4), 317–332. https://doi.org/10.1111/dom.12596

This post was written by our team of health writers for informational purposes only and does not constitute medical advice. Always consult your doctor or healthcare provider for personalized guidance regarding your health. Ozempic®, Wegovy®, Mounjaro®, and Zepbound® and their delivery device are registered trademarks. Mochi Health is a telehealth clinic that offers prescriptions for these products by medical necessity only as determined by a licensed health provider.