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Does Mounjaro® Cause Insomnia?
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Weight loss
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Can Mounjaro® Help With Insomnia and Sleep Quality?
Findings from clinical trials indicate that addressing obesity can alleviate weight-related sleep issues, although it’s uncertain whether Mounjaro® directly causes or treats sleep apnea.
Obstructive sleep apnea (OSA), though different from insomnia, disrupts sleep by causing repeated drops in oxygen levels during the night. This leads to symptoms like daytime sleepiness, morning headaches, and trouble concentrating.
According to Eli Lilly’s SURMOUNT-OSA phase 3 clinical trials, higher doses of Mounjaro® (10mg and 15mg) reduced the frequency of these apneic events by as much as 30 events per hour (9).
Losing weight can also alleviate symptoms of depression, which often include sleep disturbances like insomnia (5,6,7,8). While more studies are needed to confirm if weight loss completely resolves depression and its associated symptoms, it's worth noting that insomnia is a common sign of depression. By addressing weight loss, Mounjaro® may indirectly alleviate insomnia.
Managing Your Sleep & Overall Health With Mounjaro
While Mounjaro® is not primarily associated with insomnia, indirect effects of weight loss or metabolic changes could potentially affect sleep. If you're experiencing difficulties sleeping while taking Mounjaro®, it's paramount to address these issues with your healthcare provider to find a suitable solution. Managing side effects is an important part of the process throughout your medication-assisted weight loss journey.
Connect with a Mochi Health provider for tailored guidance from an obesity medicine specialist. Our program at Mochi Health includes personalized weight care, access to GLP-1 medications, and expert support every step of the way. Check your eligibility and start your health transformation today.
References:
Ramar K, Malhotra RK, Carden KA, et al. Sleep is essential to health: an American Academy of Sleep Medicine position statement. J Clin Sleep Med. 2021;17(10):2115–2119.
Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine. 2022;387(3). doi:https://doi.org/10.1056/nejmoa2206038
Malhotra, A., Bednarik, J., Chakladar, S., Dunn, J. P., Weaver, T., Grunstein, R., Fietze, I., Redline, S., Azarbarzin, A., Sands, S. A., Schwab, R. J., & Bunck, M. C. (2024). Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial. Contemporary Clinical Trials, 141, 107516–107516. https://doi.org/10.1016/j.cct.2024.107516
Martens, K., Hamann, A., Miller-Matero, L. R., Miller, C., Bonham, A. J., Ghaferi, A. A., & Carlin, A. M. (2021). Relationship between depression, weight, and patient satisfaction 2 years after bariatric surgery. Surgery for Obesity and Related Diseases, 17(2), 366–371. https://doi.org/10.1016/j.soard.2020.09.024
Patsalos, O., Keeler, J., Schmidt, U., Penninx, B. W. J. H., Young, A. H., & Himmerich, H. (2021). Diet, Obesity, and Depression: A Systematic Review. Journal of Personalized Medicine, 11(3), 176-. https://doi.org/10.3390/jpm11030176
Fabricatore, A. N., Wadden, T. A., Higginbotham, A. J., Faulconbridge, L. F., Nguyen, A. M., Heymsfield, S. B., & Faith, M. S. (2011). Intentional weight loss and changes in symptoms of depression: a systematic review and meta-analysis. INTERNATIONAL JOURNAL OF OBESITY, 35(11), 1363–1376. https://doi.org/10.1038/ijo.2011.2
Cooper, D. H., Ramachandra, R., Ceban, F., Di Vincenzo, J. D., Rhee, T. G., Mansur, R. B., Teopiz, K. M., Gill, H., Ho, R., Cao, B., Lui, L. M. W., Jawad, M. Y., Arsenault, J., Le, G. H., Ramachandra, D., Guo, Z., & McIntyre, R. S. (2023). Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review. Journal of Psychiatric Research, 164, 80–89. https://doi.org/10.1016/j.jpsychires.2023.05.041
This post was written by our team of health writers for informational purposes only and does not constitute medical advice. Always consult your doctor or healthcare provider for personalized guidance regarding your health. Ozempic®, Wegovy®, Mounjaro®, and Zepbound® and their delivery device are registered trademarks. Mochi Health is a telehealth clinic that offers prescriptions for these products by medical necessity only as determined by a licensed health provider.
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