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Orlistat for Weight Loss: How Does Orlistat Work
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Weight loss

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Orlistat Administration and Dosage
Orlistat can be given in a prescription form (Xenical)or over-the-counter form (Alli). Xenical is started as a 120 mg pill taken three times a day with each main meal that contains fat. Alli is given as a 60mg pill in the same manner. Either form should be taken during a meal or up to one hour after. If a meal has no fat, then you can skip the dose.
This medication must be taken with a nutritionally balanced, reduced-calorie diet containing approximately 30% of calories from fats. It is also important to ensure you efficiently take fat-soluble vitamin supplements (D, E, A, and K) to prevent deficiency. Also, you may benefit from taking supplements or eating foods that contain healthy fats, such as Omega 3 and Omega 6 fatty acids. For best results, you should also engage in regular exercise of about 150 minutes per week.
Orlistat Side Effects
Since Orlistat effectively prevents your body from absorbing fats, one of the most common side effects patients notice is oily or fatty stools. Other common side effects include oily spotting in your underwear, gas, loose stools, stomach pain, and nausea. You may become deficient in fat-soluble vitamins, which include vitamins D, K, A, and E. You may also reduce the amount of essential fats (Omega 3, Omega 6) you take daily. Therefore, you must take this medication under the supervision of a licensed medical provider and take supplements to replace these lost vitamins and fats.
Cost and Coverage
Orlistat is available over the counter or as a prescription medication. The over-the-counter version, Alli, can cost around $50-$65 for a 30-day supply. Xenical can cost up to $555 for a 30-day supply. For this reason, your provider may recommend starting with Alli. You may be eligible for a Xenical Coupon to help cover the price.
Where Can I Learn More?
If you would like to learn more about GLP-1 medications or want to see if you might be eligible for medication-assisted weight loss, check out Mochi Health, where board-certified obesity medicine physicians can offer expertise in this realm!
References:
Sjöström L, Rissanen A, Andersen T, Boldrin M, Golay A, Koppeschaar HP, Krempf M. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group. Lancet. 1998 Jul 18;352(9123):167-72. doi: 10.1016/s0140-6736(97)11509-4. PMID: 9683204.
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